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Lubricant Eye Drops


LONG-LASTING Dry Eye relief 1,2,3 with dual-action hydration


Feel unstoppable every day with this advanced hydration formula, a combination of HP-Guar & Hyaluronic acid proven to deliver LONG-LASTING1,2,3 relief. Systane® HYDRATION is also recommended for LASIK or cataract patients seeking Dry Eye symptom relief2,5.

Systane® Hydration Lubricant Eye Drops carton and product box

Key Benefits


  • LONG-LASTING RELIEF for irritated, dry eyes1,2,3,
  • Reduced Dry Eye symptoms in post-surgical patients4
  • Easy to use Multi-dose Drop-Tainer™ bottle
  • For moderate, chronic sufferers*
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Product Information & Usage


Product Information

  • For Aqueous (Water) Deficient Dry Eye

  • Dual-action hydration of the ocular surface1

  • 2X greater moisture retention1 (compared to HA alone formulation)

  • Hydrates and helps restore damage cells on ocular surface for long lasting dry eye relief1 -3

  • Available sizes: 10mL Drop-Tainer™ bottle. Also available in a 30ct unit dose vial

Product Usage

  • May be used as needed throughout the day

  • Place 1 or 2 drops in the affected eye(s) as needed and blink

  • Can be used with contact lenses**

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    Systane® HYDRATION is a preserved formulation suitable for occasional users, which contains a very small quantity of the preservative (POLYQUAD™ 0.001%). Systane® HYDRATION UD PRESERVATIVE-FREE lubricant eye drop is a preservative-free formulation, suitable for frequent users and available in a 30ct unit dose vial.

    Yes, Systane® HYDRATION lubricant eye drops can be used while wearing contact lenses.

    Systane® HYDRATION 10mL bottles can be used for 3 months after opening as long as the product has not expired. The 3mL sample size bottles can be used for 3 months after opening.  Always check the label for the expiration date.

    Ingredients & Safety


      Contains: Sodium hyaluronate, polyethylene glycol 400, propylene glycol, hydroxypropyl guar, sorbitol, aminomethyl propanol, boric acid, sodium borate, disodium EDTA, sodium citrate, potassium chloride, sodium chloride, POLYQUAD™ (polyquaternium-1) 0.001% preservative, and purified water. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.

      For ocular use only.

      Do not use if solution changes color or becomes cloudy.

      When using this product do not touch tip of container to any surface to avoid contamination and replace cap after each use. To avoid contamination, never touch the dropper tip of the container to any surface. Replace cap after using.

      Stop using and consult your eye care professional if you experience:

      • Persistent eye discomfort

      • Vision changes

      • Excessive tearing

      • Redness of the eye

      Keep out of reach of children. If swallowed, get medical help.

      *Based on internal assessment and patient segmentation
      **Please refer to relevant instructions for use


      1. Rangarajan R, Kraybill B, Ogundele A, Ketelson H. Effects of a hyaluronic acid/hydroxypropyl guar artificial tear solution on protection, recovery, and lubricity in models of corneal epithelium. J Ocul Pharmacol Ther. 2015;31(8):491-497. 
      2. Davitt WF, Bloomenstein M, Christensen M, Martin AE. Efficacy in patients with dry eye after treatment with a new lubricant eye drop formulation. J Ocul Pharmacol Ther. 2010;26(4):347-353. 
      3. Rolando M, Autori S, Badino F, Barabino S. Protecting the ocular surface and improving the quality of life of dry eye patients: a study of the efficacy of an HP-guar containing ocular lubricant in a population of dry eye patients. J Ocul Pharmacol Ther. 2009;25(3):271-278.

      4. Davidson R, Schultz-Scott B. Efficacy Evaluation of SYSTANE® ULTRA in Patients With Dry Eye Undergoing Cataract Surgery. Poster presented at: 30th Congress of the European Society of Cataract and Refractive Surgeons; September 8-12, 2012; Milan, Italy.
      5. Favuzza E, Cennamo M, Vicchio L, Giansanti F, Mencucci R. Protecting the Ocular Surface in Cataract Surgery: The Efficacy vof the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution. Clin Ophthalmol. 2020 Jun 26;14:1769-1775.


      Consult your healthcare or eye care professional for use, precautions, warnings and contraindications.